قسم الكيمياء الصيدلية (أعلانات للطلبة)

Fourth Year Practical Exam Course 801

2011-01-07T00:21:00.041+02:00

2010-12-31T14:40:00.001+02:00

The best 12 projects are those of groups:
- 139-149
- 279-289
- 383-393
- 476-486
- 555-563
- 730-742+ 415
- 835-843
- 878-886
- 929-939
- 1000-1010
- 1144-1155
- 1183-1190

Computer Aided Drug Design

2010-11-24T11:29:00.023+02:00

Project Presentation

2010-11-17T12:36:00.002+02:00

آخر ميعاد لتسليم ال Projects يوم 25\11\2010

عرض و مناقشة Projects سيتم يومي 2و9\12\2010 مع معامل المراجعه

يجب على كل عارض أن يستغرق 10 دقائق فقط

يوم 16\12\2010 إمتحان ال Purity عملى

Dead line for submitting the research projects is the twentyfifth of November

The Project presentation will be held on the second and ninth of december during revision labs

Each presentation duration should only last 10 minutes

Purity Exam will be held on the 16th of december

Quiz Exam

2010-11-10T11:30:00.004+02:00

يعقد إمتحان Quiz يوم الخميس 25\11\2010

كل في معمله

يشمل الإمتحان

* الأجزاء التاليه من النظرى

Hormones, Drug metabolism, Drug design part 1

* نظرى العملى

2010-10-23T12:03:00.003+02:00

ستقام مجموعه للسنه الرابعه pharmaceutical chemistry 801
المحاضرة الأولى مجانيه يلقيها الدكتور إيهاب القاضى
يوم الإثنين 8\11 الساعه الرابعه والنصف مساء بمدرج رجب فهمي

Practical_2010-2011

2010-10-23T11:20:00.048+02:00

2010-10-22T17:34:00.037+02:00

2010-10-20T11:04:00.005+02:00

*الفرقة الرابعه حديث 801
مجموعه أ الساعه 11ص إلي الساعه 12م

Lecture (Corticosteroids) + Revision

مدرج الدراسات العليا

*الفرقه الرابعه حديث 801

مجموعه (ب) من الساعه 12م إلى الساعه 1 م

بقية محاضرة corticosteroids

+ revision

مدرج الدراسات العليا

Simple Questions on Sex hormones

2010-10-13T16:40:00.024+02:00

Assign true or false:

-In steroidal nucleus substituents at positions c-9 and c-14 have alpha configuration.

-Estrane nucleus has one angular methyl at c-10.
-Estradiole is convertedd to esterone by 16 alpha hydroxylase.

-Estradiole with 17 alpha OH has optimum activity.

-Estrogentic acitivity does not require a strict structural configuration.

Complete:

-17 hydroxy pregenenolone is converted to dehydro epiandrosterone via the loss of....................

by enzyme.................

-Estrogens prevent coronary artherosclerosis in women because of………………………………………………………

- Estrogens are used in combination with progestins as ………

- Estramustine phosphate is a selective drug to treat prostatic cancer by 2 mechanisms. Mention these mechanisms with reason for selectivity.

-To avoid oxidation of 17-OH group in estradiol insert substituent at position ……The same group can be inserted into testosterone to avoid metabolism with retaining androgenic activity..(True/false) choose the right answer with reason.

-Androstenedione is converted to testosterone via the enzyme …..

-Attenuated estrogens exemplified by …….. are used in postmenopausal women as ………………….

Choose the correct answer :

-Estriol produce

1. Strong estrogenic effects

2. Strong and persistent binding to estrogenic receptor without conformational changes.

3. Impede access of estradiol to receptor sites.

Clomiphene citrate is used to treat infertility as
1.Zuclomiphene
2. Enclomiphene
3. A mixture of the two isomers
Rationalize your answer.

Triazole derivatives are used to treat estrogen-dependent breast cancer in postmenopausal women by Inhibiting
1. Aromatase.

2. Estradiol dehydrogenase.

3. 17-keto reductase.

Decreased level of 5β-pregnanediol in urine of pregnant women is indicating

1. Increased level of estrogens
2. Increase level of progestins.
3. Decreased level of progestins.

Oppenauer oxidation is used to

1. Oxidize secondary alcohol to ketone
2. Oxidize secondary alcohol to tertiary alcohol.
3. Oxidize primary alcohol to ketone
Mention names of used reagents in this oxidation.

Dydrogesterone used to maintain pregnancy is a derivative from

1. Nor-androstane nucleus
2. Estrane nucleus
3. Pregnane nucleus
It produces androgenic/ no androgenic effects (choose).

Complete:

- Deactivation of testosterone gives ………….. and ………….while active steroids can be obtained via ….. enzyme to give and via ………. Enzyme to give ………
- Endometriosis can be treated either with a …………..
hormone e.g…………. or attenuated androgen e.g. ….
- Inhibition of 5α-reductase which convert ……………. To ……….. can be performed with ……….. or …………

-Conversion of 17 ethynyl to ethyl group in compound (I) gives compound ……………….(generic name) which is used as …….
- Removal of 3-keto function from compound (I) gives compound ………………….(generic name) which is used as …………………. Without……… effect.
-From compound (II) make two different modifications on ring A to obtain two different anabolic agents.

1st modification ……..
.

structure ………….................................................................. generic name……………….

2nd modification ……………
.

Structure ……… .......................................................generic name ……………

●Choose the appropriate compound for each case, give generic name of your chosen compound and reason for your choice
-A postmenopausal women suffering from osteoporosis, can be treated with compound A or B.

__To increase weight and to reverse loss of protein resulting from whatever any case, a child can use compound A or B.

tuesday 5-10-2010

2009-11-08T20:58:00.007+02:00

جدول الساعات المكتبيه لأعضاء هيئه التدريس للفرقة الرابعة (801) لخريف 2010\2011

Fall 2010-2011

الأسم	الحجرة	اليوم	الساعة
أ.د نهاد أبو المجد السيد		الأثنين و الخميس	10 ص - 12 م
أ.د صافيناز السيد عباس		الثلاثاء و الخميس	10 ص - 12 م
أ.م مني موريس حنا		الثلاثاء و الخميس	10 ص - 12 م
أ.م عنايات إبراهيم علي		الخميس	10 ص - 2 م
أ.م حنان حنا جورجي		الثلاثاء و الخميس	9 - 11 ص
د.هناء عبد المنعم هاشم		الأربعاء و الخميس	10 ص - 12 م
د. ريهام فرانسواه جورج		الأثنين و الثلاثاء	9 ص - 1 م

Simple Questions on Sex hormones

2009-11-08T11:55:00.021+02:00

Assign true or false
-In steroidal nucleus substituents at position C-9 and C-14 have α configuration.
- Estrane nucleus has one angular methyl at C-10
-Estradiol is converted to estrone by 16α-hydroxylase
- Estradiol with 17α-OH has optimum activity
-Estrogenic activity does not require a strict structural configuration.
Complete
-17-Hydroxypregnenolone is converted to dehydro-epiandrosterone via loss of ……………… by enzyme …………..
-Estrogens prevent coronary artherosclerosis in women because of ………………………………………………………
- Estrogens are used in combination with progestins as ………
- Estramustine phosphate is a selective drug to treat prostatic cancer by 2 mechanisms. Mention these mechanisms with reason for selectivity.
_To avoid oxidation of 17-OH group in estradiol insert substituent at position ……The same group can be inserted into testosterone to avoid metabolism with retaining androgenic activity.(True/false) choose the right answer with reason.

-Androstenedione is converted to testosterone via the enzyme …..
-Attenuated estrogens exemplified by …….. are used in postmenopausal women as ………………….

-Choose the correct answer
-Estriol produce
1. Strong estrogenic effects
2. Strong and persistent binding to estrogenic receptor without conformational changes
3. Impede access of estradiol to receptor sites

Clomiphene citrate is used to treat infertility as
1.Zuclomiphene
2. Enclomiphene
3. A mixture of the two isomers
Rationalize your answer.

Triazole derivatives are used to treat estrogen-dependent breast cancer in postmenopausal women by Inhibiting
1. Aromatase
2. Estradiol dehydrogenase
3. 17-keto reductase

Decreased level of 5β-pregnanediol in urine of pregnant women is indicating
1. Increased level of estrogens
2. Increase level of progestins.
3. Decreased level of progestins.

Oppenauer oxidation is used to
1. Oxidize secondary alcohol to ketone
2. Oxidize secondary alcohol to tertiary alcohol.
3. Oxidize primary alcohol to ketone
Mention names of used reagents in this oxidation.

Dydrogesterone used to maintain pregnancy is a derivative from
1. Nor-androstane nucleus
2. Estrane nucleus
3. Pregnane nucleus
It produces androgenic/ no androgenic effects (choose)

Complete
- Deactication of testosterone gives ………….. and ………….while active steroids can be obtained via ….. enzyme to give and via ………. Enzyme to give ………
- Endometriosis can be treated either with a …………..
hormone e.g…………. or attenuated androgen e.g. ….

- Inhibition of 5α-reductase which convert ……………. To ……….. can be performed with ……….. or …………

............(I)................................................... ............................................ .(II)

-Conversion of 17 ethinyl to ethyl group in compound (I) gives compound ……………….(generic name) which is used as …….
- Removal of 3-keto function from compound (I) gives compound ………………….(generic name) which is used as …………………. Without……… effect.
-From compound (II) make two different modifications on ring A to obtain two different anabolic agents

1st modification ……..

structure ………… generic name……………….
2nd modification ……………

Structure ……… generic name ……………

●Choose the appropriate compound for each case, give generic name of your chosen compound and reason for your choice
-A postmenopausal women suffering from osteoporosis, can be treated with compound A or B.

.............................. (A) ...................... ........................ ............................................(B)

Compound No ,generic name…… reason …..

__To increase weight and to reverse loss of protein resulting from whatever any case, a child can use compound A or B.

........................ (A) ......................... ....................................................................... (B)

الساعات المكتبية لأعضاء هيئة التدريس بالقسم

2008-12-16T11:16:00.003+02:00

أ.د/ نهاد أبو المجد السيد
الاثنين - الأربعاء
11- 30:12
أ.د/ سونيا طلعت حسيب
الاثنين - الثلاثاء

أ.د/ فاطمة عبد الفتاح رجب
الأحد - الخميس
11 – 30:12
أ.د/ كاميليا محمود أمين
الاثنين – الثلاثاء
11-1 – 11-12
أ.د/ بهية عباس موسى
الثلاثاء - الخميس

أ.د./ صافيناز السيد عباس
الثلاثاء - الخميس
9 -11 – 10 - 11
أ.د/ رمزية إسماعيل البقرى
الأحد - الاثنين
10 – 30:11
د/منى موريس حنا
الاثنين - الأربعاء
11 – 30:12
د / عنايات إبراهيم على
الأحد – الأربعاء
10-12 – 11-12
د/ نجوى محمد عبد الجواد
الاثنين الأربعاء
11 – 30ر12
د0 / أمل عبد الحليم عيسى
الاثنين - الثلاثاء
11 – 30ر12
د0 / فلورا فائق برسوم
الاثنين - الثلاثاء
11 – 30ر12
د/ عواطف السعيد فرج
الاثنين - الأربعاء
12- 1 – 11 -12
د/ هناء عبد المنعم هاشم
الأحد - الثلاثاء
11 – 30:12
د / حنان حنا جورجى
الاثنين - الأربعاء
10 -12 – 10-11
د / دعاء عزت عبد الرحمن
الأحد - الاثنين
11 – 30:12
د/ فادى محسن عوض الله
الأربعاء - الخميس
10-11 – 9 - 11
د / ريم محمد خضر عرفة
الأحد - الاثنين
11 – 30:12
د. ماريان الفونس
الاثنين - الثلاثاء
10:30- 12 - 11:30 -1

hormone questions 801 26/11/2008

2008-11-26T13:39:00.030+02:00

Assign true or false

-In steroidal nucleus substituents at position C-9 and C-14 have α configuration.
- Estrane nucleus has one angular methyl at C-10
-Estradiol is converted to estrone by 16α-hydroxylase
- Estradiol with 17α-OH has optimum activity
-Estrogenic activity does not require a strict structural configuration.

Complete
-17-Hydroxypregnenolone is converted to dehydro-epiandrosterone via loss of ……………… by enzyme …………..
-Estrogens prevent coronary artherosclerosis in women because of ………………………………………………………
- Estrogens are used in combination with progestins as ………
- Estramustine phosphate is a selective drug to treat prostatic cancer by 2 mechanisms. Mention these mechanisms with reason for selectivity.
_To avoid oxidation of 17-OH group in estradiol insert substituent at position ……The same group can be inserted into testosterone to avoid metabolism with retaining androgenic activity.(True/false) choose the right answer with reason.
-Androstenedione is converted to testosterone via the enzyme …..
-Attenuated estrogens exemplified by …….. are used in postmenopausal women as ………………….
Choose the correct answer
-Estriol produce
1. Strong estrogenic effects
2. Strong and persistent binding to estrogenic receptor without conformational changes
3. Impede access of estradiol to receptor sites

Clomiphene citrate is used to treat infertility as
1.Zuclomiphene
2. Enclomiphene
3. A mixture of the two isomers
Rationalize your answer.

Triazole derivatives are used to treat estrogen-dependent breast cancer in postmenopausal women by Inhibiting
1. Aromatase
2. Estradiol dehydrogenase
3. 17-keto reductase

Decreased level of 5β-pregnanediol in urine of pregnant women is indicating
1. Increased level of estrogens
2. Increase level of progestins.
3. Decreased level of progestins.

Oppenauer oxidation is used to
1. Oxidize secondary alcohol to ketone
2. Oxidize secondary alcohol to tertiary alcohol.
3. Oxidize primary alcohol to ketone
Mention names of used reagents in this oxidation.

Dydrogesterone used to maintain pregnancy is a derivative from
1. Nor-androstane nucleus
2. Estrane nucleus
3. Pregnane nucleus
It produces androgenic/ no androgenic effects (choose)

Complete
- Deactication of testosterone gives ………….. and ………….while active steroids can be obtained via ….. enzyme to give and via ………. Enzyme to give ………
- Endometriosis can be treated either with a …………..
hormone e.g…………. or attenuated androgen e.g. ….

- Inhibition of 5α-reductase which convert ……………. To ……….. can be performed with ……….. or …………

(I) ...................................................................................(II)

1st modification ……..

...............structure ………… .................generic name……………….

2nd modification ……………

...............Structure ……… .....................generic name ……………

●Choose the appropriate compound for each case, give generic name of your chosen compound and reason for your choice
-A postmenopausal women suffering from osteoporosis, can be treated with compound A or B.

............ A ......................................................B

Compound No. ,generic name…… reason …..

__To increase weight and to reverse loss of protein resulting from whatever any case, a child can use compound A or B.

.........................m ..............A ..........................................B

4-11-2008

2008-11-04T13:01:00.004+02:00

أكاديمية البحث العلمى والتكنولوجيا

تقدم الأكاديمية عدد من المنح السنوية لأوائل الخرجين للإلتحاق بالجامعات والمعاهد البحثية كطلاب منح تيسيرا لحصولهم على درجة الماجستير وذلك حسب الرغبات التى تتقدم بها تلك الجامعات والمراكز البحثية.
التفاصيل لدى سكرتارية القسم.

سكرتارية القسم :

عنهم هدى رشاد

اعلان لطلبة الدراسات العليا

2008-10-09T13:16:00.001+02:00

سيتم باذن الله بدء محاضرات الدراسات العليا لطلاب الماجستير ( كيمياء صيدلية ) اعتبارا من 14/10/2008 يوم ( الثلاثاء من كل اسبوع )

9-10-2008

2008-10-09T12:43:00.002+02:00

اعلان لطلبة الفرقة الرابعة نظام حديث (801)

Lecturer ................................,...Topic...........................Grades

Prof. Dr. Nehad Abuelmagd................. .......Hormones .........................................23

Dr. Awatef Alsaied........................................Drugdesigl...........................................18

Dr. Hanan Hanna.....................................Drugmetabolism......................................21

Dr.FadiMohsen.............................................QSAR,CADD,.......................................18

Physicochemical properties

mechamism-based drug design

Antioxidants,antiaging

Total 80 marks........................................................................................................

Oral 20 marks

:Prectical exams

Physicochemical Properties 15 marks

Limit Test 20

Sheet 10

Lab Performance 5

Practical Total 50 Marks

29-9-1009

2008-09-27T19:08:00.006+02:00

تنبيهات هامة لطلبة السنة الرابعه والخامسة (نظام حديث) وطلبة السنة الرابعة (نظام قديم)

1-أولا طلبة السنة الخامسة (نظام حديث) 803

علىطلبة السنة الخامسة نظام حديث احضار الأدوات التالية:

1-Conical flask 250 or 500 cc

2-Glass-stoppered conical flask 250 0r 500 cc

3-Calibrated Burrette 25 or 50 cc

4-Standard pipettes 10 and 20 cc

5-Separating funnel 150 cc

6-One pair of matching Nesler tubes

7-Five test tubes

8-Filtration funnel

9-Beaker 150 cc

10-Filter papers.

11-Bulb-pipette

وذلك لأسخدامها فى المعامل الخاصة بالكيمياء الصيدلية حيث تبدأ المعامل الخاصة بالسنة الخامسة حديث 803 يوم الثلاثاء 7 أكتوبر

2-ثانيا السنة الرابعة (نظام حديث) 801

على طلبة السنة الرابعة (نظام حديث) احضار الأدوات التالية:

1-Beaker 250 cc.

2-Conical Flask 250 cc.

3-Standard pipette 10 cc.

4-Graduated pipette 10 cc.

5-Calibrated Burrette 25 cc.

6-A pair of matching Nesler tubes.

7- Ten test tubes

8-Filtration funnel.

9-Filter papers.

وذلك لأسخدامها فى المعامل الخاصة بالكيمياء الصيدلية حيث تبدأ المعامل الخاصة حيث تبدأ المعامل الخاصة بالسنة الرابعة حديث 801 يوم الأثنين 13 أكتوبر.

3-ثالثا طلبة السنة الرابعة نظام قديم

علىطلبة السنة الرابعة نظام قديم احضار الأدوات التالية:

1-Conical flask 250 or 500 cc
2-Stoppered conical flask 250 0r 500 cc
3-Calibrated Burrette 25 or 50 cc
4-Standard pipettes 10 and 20 cc
5-One pair of matching Nessler tubes
6-Five test tubes
7-Filtration funnel
8-Beaker 150 cc
9-Filter papers.

وذلك لأسخدامها فى المعامل الخاصة بالكيمياء الصيدلية حيث تبدأ المعامل الخاصة بالسنة الرابعة (نظام قديم) يوم الخميس 9 أكتوبر

11/9/2008

2008-05-18T12:46:00.003+03:00

اعـــــــــلان لطلاب الفرقة الرابعة والخامسة

(نظام حديث )

سيعقد مؤتمر القسم للعام الدراسى 2008 /2009 يوم الثلاثاء الموافق 23/9/2008 الساعة الحادية عشر صباحا بمدرج الدراسات العليا والدعوة مفتوحة للطلبة للحضور للمشاركة وابداء الرأى